ExRNA

Table 2 Pharmacokinetics analysis of plasma miR time curves after milk meal in healthy adults^a

From: MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response

Variable	miR-15b-5p	miR-21-5p	miR-106b-5p	miR-223-3p	miR-1-3p
Baseline^b, fmol/L	682 ± 150	2048 ± 190	400 ± 110	822 ± 120	94 ± 9.8
C_max, fmol/L	1289 ± 360	5048 ± 940^b	641 ± 140	2152 ± 570^a	99 ± 4.9
% increase^c	89 ± 11.80	147 ± 23.20	60 ± 9.80	162 ± 31.80	–
t_max, h	3.7 ± 0.3	3.2 ± 0.6	4.1 ± 0.5	3.8 ± 0.7	–
AUC^d, (fmol/L) × h	3018 ± 120^c	12,669 ± 760^c	1531 ± 48^c	5377 ± 320^c	–

^aValues are means ± SEM, n = 12. ^aP < 0.05, ^bP < 0.01, ^cP < 0.0001, vs. baseline. AUC Area under the plasma concentration versus time curve, C_max Maximal plasma concentration, miR MicroRNA, t_max Time of peak concentration
^bPlasma concentration at time 0 h
^cC_max vs. baseline
^dFor hours 0–9

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